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44 In this manner, activating KRAS mutations induce persistent stimulation of downstream signaling cascades via direct interaction with the RAS-binding domain (RBD) of effector proteins

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Plasma levels of malondialdehyde (MDA) were substantially higher and melatonin levels were substantially lower in smokers than non-smokers, which appears that melatonin can lessen the respiratory system damage caused by free radicals brought on by cigarette smoke (67)