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Clinical trial data demonstrates that gastrointestinal side effects typically peak during the first few weeks after starting treatment or increasing the dose, then gradually diminish

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In particular, they target areas that are important for homeostatic feeding, such as the hypothalamus, and for hedonic responses, such as the nucleus accumbens (NAc), ventral tegmental area (VTA), and laterodorsal tegmental area (LDTg) ( PPG gene is also expressed in the olfactory bulb (Merchenthaler et al., 1999), amygdala, striatum, and hippocampus (Vallof et al., 2019a)

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The FDA has also warned that SARMs can have serious side effects including an increased risk of stroke [27]