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In the 1970s, GIP was identified as the first incretin hormone

This is in contrast to GLP-1R agonists, which require glutamatergic but not GABAergic neurons to drive food intake reduction and weight loss [50]

The cardiovascular benefit is independent of the degree of weight reduction achieved, which changes how physicians frame the risk-benefit conversation

Primarily, iron serves as a core component of hemoglobin, supporting oxygen delivery to tissues, and is also involved in myoglobin, cytochromes, and various enzymes (2, 4)