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This expanded protocol ensures that tirzepatide does not interfere with thyroid medication dosing or cause compensatory changes in thyroid hormone production

Dose Increases and Treatment Adjustment Headaches may appear after the first injection or following a dose increase because appetite suppression and gastrointestinal symptoms can become more noticeable during dose escalation

Permanent IGF-1 elevation

Abnormal cortisol levels require specialist endocrinology assessment and management