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Kan J, Cheng J, Hu C, et al

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Hepatol (2016) 63:26183

The cells are returned to the patient while the plasma is removed and replaced with another fluid (typically albumin or fresh frozen plasma), thus removing the toxic substance from the patient.[19] It is best suited for large molecules, especially those located intravascularly, but small molecules that are highly protein-bound (like amlodipine) are often effectively removed.[15] According to the American Association of Blood Banks and the American Society of Apheresis, therapeutic plasma exchange for acute drug overdose is a Category II recommendation