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treatment of DIO mice with either vehicle, acyl-GIP 13,14,15 (150 nmol kg 1 ), acyl-GLP-1 (50 nmol kg 1 ) 13,14,15 , the acylated peptide GIPR antagonist (1,500 nmol kg 1 ) 22 or the GIPR:GLP-1R co-agonist MAR709 (50 nmol kg 1 ) 13,14,15 (Fig

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Age-related increases in cardiac iron levels were observed in a hemochromatosis mouse model, which suggests that iron deposition and elevated levels of oxidative stress occurred [153]

Acknowledgements We gratefully acknowledge the valuable cooperation of Huiping Ma (Center of Animal Experiment, Chinese Peoples Liberation Army Joint Logistic Support Force 940th Hospital) in preparing this animal model experiment