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The release of the peptide from polymeric resin occurs with Pd 0 (triphenylphosphine) 4 noble metal catalyst under neutral conditions in the presence of an allyl receptor as dimedone or morpholine and under strict esclusion of oxygen

In the Xenopus oocyte, over-expression of arrestin alone is not sufficient to increase DOR (Kovoor et al., 1999) or KOR (Appleyard et al., 1999) desensitization while in HEK cells, this over-expression enables morphine-induced MOR desensitization probably by increasing both G protein uncoupling and receptor internalization (Whistler and Von Zastrow, 1998)

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These findings have made the peptide a subject of considerable interest within metabolic research

If they are also used in other thiol ATs, this can potentially lead to removing their limitations (at least some of them) and enhancing their therapeutic potential