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Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression

Taking extra doses increases the risk of serious adverse events including severe gastrointestinal distress, pancreatitis, and unpredictable blood sugar changes

This finding changed the protocol for all subsequent trials

Glucagon-like peptide-1 receptor agonists have demonstrated significant weight loss and cardiovascular benefits in both patients with and without diabetes, including a reduction in major adverse cardiovascular events