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Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels

However, this study did not include a comparison group, making the results uncertain [7][21]

Understanding these timelines helps set realistic expectations and guides monitoring strategies

M.GaisinA.et al (2021)

The most common side effects reported were mild gastrointestinal symptoms like nausea, diarrhea, and constipation, similar to those found in earlier trials