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Semaglutide is generally safe when used under the guidance of a healthcare provider, but it may not be suitable for everyone

Compared to placebo, first line use of SGLT2i significantly reduced glycosylated hemoglobin type A1C (HbA1c) (MD: -0.72), weight (MD: -1.32) and fasting plasma glucose (FPG) (MD: -27.05) levels

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The Work Group judged mild to severe drug-related AEs in the target and general population as being highly important

Typical progression: Week 12 Improved energy levels Week 34 Better endurance Week 6+ Gradual fat loss Studies indicate modest fat loss (~1 kg over time) when combined with exercise