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Until recently, cardiac safety assays predominantly involved high-throughput screening of HERG blockade early on and a so-called thorough QT study assessing repolarization prolongation in humans later on in drug development
In the Increlex (native mecasermin) FDA-approved program, hypoglycemia was reported in 42% of subjects, with five subjects experiencing severe episodes requiring assistance and four experiencing seizures or loss of consciousness
Reported mild side effects include nausea, dizziness, and irritation at the injection site, and the compound is generally well tolerated with minimal side effects in research settings
Human chorionic gonadotropin (hCG) is commonly prescribed in the UK alongside testosterone replacement therapy (TRT), particularly where preservation of testicular function or fertility is a clinical consideration
