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14 With the decline in renal function that occurs with aging, older individuals are not able to excrete excess hydrogen ions, and they develop mild but slowly increasing metabolic acidosis

As such, it creates a substantial health burden and a parallel need for medicines to support weight reduction

A.WertS

Drug metabolism and immunological mechanisms Drugs are generally transformed to biologically inactive structures and eliminated from the body, chiefly by hepatic metabolism

Marcio de Souza Duarte, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers