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Though it is not universal, a fair percentage of those on a ketogenic diet become L-carnitine deficient (absolute or relative), and demonstrate better control of epileptic events, as well as respond better to medication when supplemented with L-carnitine
IGF-1 receptor and adhesion signaling: An important axis in determining cancer cell phenotype and therapy resistance
It is the master endogenous antioxidant it neutralizes reactive oxygen species, regenerates vitamins C and E to their active forms, and serves as the substrate for phase II liver detoxification
Kitamura, S
It accumulates as unmetabolized folic acid (UMFA) and competes with active folates for receptors. Conversion between the two active forms is unreliable : it requires multiple enzymes (MTR, MTRR, SHMT, MTHFR, MTHFS) all working properly, and is easily blocked by low glutathione, B12 deficiency, heavy metals, or oxidative stress
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