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Additionally, there was a significant reduction in HF-related events with semaglutide

Knockdown of preproglucagon expression in the hindbrain as well as central GLP-1R antagonism results in hyperphagia and body weight gain in rats indicating that these neurons are essential for maintenance of normal body weight (Barrera et al., 1996)

Diabetologia (2011) 54(1):108

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