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Brain Sciences (2021) This study by an independent research group (outside the original Washington State University team) demonstrated that Dihexa rescues cognitive impairment in an Alzheimer's disease mouse model (APP/PS1 transgenic mice)

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There is a large interindividual variation in CYP2C9 activity in the population with resulting interindividual variations in drug response and also in adverse effects

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During the course of the study, there was no change to the therapeutic regime other than the introduction of parenteral cobalamin supplementation