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Patients who stop lipotropics abruptly without B12 continuation often report fatigue, brain fog, and reduced exercise tolerance

Witte ME, Lars B, Rodenburg RJ, Belien JA, Musters R, Hazes T, Wintjes LT, Smeitink JA, Geurts JJG, De Vries HE, Van Der Valk P, Van Horssen J (2009) Enhanced number and activity of mitochondria in multiple sclerosis lesions

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Further analysis showed that blood lipid and liver function markers (ALT, AST, TC, TG, LDL-C) were markedly higher in db/db mice, whereas HDL-C levels were notably decreased