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Side effects and risks of lipase inhibitors The most common side effects of orlistat are gastrointestinal, including: Loose, greasy stools Diarrhea Gas (flatulence) Leakage of feces (poop) onto underwear or clothes Abdominal pain Tears in the anus Because orlistat works by blocking fat absorption and removing excess fat as waste, these side effects may be more common after eating high-fat foods or meals

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For those receiving retatrutide outside a trial setting (for example, via named-patient supply), contact your dispensing pharmacist or prescribing clinician promptly

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Contact your GP if you experience severe or worsening joint pain, joint swelling or redness, sudden intense pain in a single joint, persistent pain lasting more than two weeks, or joint stiffness lasting over 30 minutes after waking