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Resected pancreatic tissue was enzymatically and mechanically dissociated to yield a remnant cell pellet containing islets (identified by dithizone staining) and ductal fragments, from which PDECs can be microdissected, embedded in matrigel, and expanded as 3D organoids

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Conversely, if nausea, vomiting, or gastrointestinal distress limits your food intake to dangerously low levels on a low dose, that's a sign your body is over-responding, and dose reduction may be necessary

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