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The two full-dose columns are the therapeutic lane, starting low and titrating up over time toward stronger appetite regulation

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Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol

Other commonly documented side effects include injection site reactions (redness, itching, or swelling), fatigue, and dizziness