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The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that fuel the adverse metabolic phenotype

These patients may display subtle metabolic abnormalities insulin resistance, dyslipidemia, or visceral adiposity despite appearing lean. Clinical markers such as waist circumference, hepatic imaging findings, and elevated liver enzymes (ALT/AST) should prompt further evaluation even when BMI is below 25 kg/m

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Protein, fibre, and other nutrients like potassium, calcium, sodium, and particular vitamins also align with eating less, but not quite as much

Effects of liraglutide on diastolic function parameters in patients with type 2 diabetes and coronary artery disease: a randomized crossover study