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*Correspondence: Zhihong Chen, [email protected] Li, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In both peptides, the N-terminal histidine sits in an enclosed pocket forming hydrophobic and hydrogen bond interactions with E364 6 .53 , E387 7 .42 , R310 5 .40 , Y241 3 .44 , W306 5 .36 , I313 5 .43 and Q234 3 .37 however, these interactions are more persistent with GLP-1, and this is likely linked to the stability of interactions of Glu9 and with residues at the base of the binding cavity (Supplemental Table 3, Supplemental Movie 1)

Stomach : GLP-1 slows digestion, prolonging satiety (feeling full) after eating