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Typically, thyroid hormone receptors are in the target cell nucleus, although they can also be found in cytoplasm in an inactive state
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doi:10.1080/1028415X.2016.1262097 Dehbokri N, Noorazar G, Ghaffari A, Mehdizadeh G, Sarbakhsh P, Ghaffary S
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Additional research considerations include characterizing whether the enhanced membrane permeability of the acetylated form alters tissue distribution in in vivo models, whether the modified charge distribution affects receptor or chromatin binding dynamics, and whether the extended half-life requires adjusted concentration protocols in cell culture systems
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