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Generally, the discomfort experienced during fillers and injectables varies depending on individual pain tolerance, the area being treated, and the specific product used
Other reported effects Beyond GI symptoms, clinical trials noted several other effects worth monitoring: Increased heart rate: A small, dose-dependent increase in resting heart rate was observed, consistent with what occurs with other GLP-1 agonists
The 12 mg row is included for completeness because the Phase 2 trial escalated through 1 mg, 2 mg, 4 mg, 8 mg and 12 mg arms, with the 12 mg cohort reaching approximately 24.2% mean weight loss at 48 weeks at the cost of a heavier nausea and constipation burden [2][5]
For diabetes, having a very long-acting treatment to influence insulin levels is very favourable