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Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis

JAMA 287, 32233229

This matters for tissue strength, healing capacity, and overall resilience, especially as hormonal changes during perimenopause affect collagen production

Upon binding to the erythropoietin receptor (EpoR, located on the surface of erythroid progenitor cells), EPO activates Jak2/STAT5, Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways [41, 42] with consequent downstream recruitment of GATA-1 transcription factor [43], a master regulator of erythropoiesis critically affecting all aspects of cell survival and proliferation

It reduces appetite through brain receptors separate from GLP-1, delays stomach emptying, and reduces post-meal blood sugar spikes