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Preservation of iBAT and muscle, alongside preferential loss of white fat, is a favorable outcome, suggesting that weight loss occurred mainly through depletion of excess adipose tissue ( Supplementary Fig

Studies at Manchester, UK, identified lower habitual intakes of selenium, vitamin C, riboflavin and vitamin E in patients with idiopathic chronic pancreatitis than in age and gender-matched controls, Selenium was the best discriminator on step-wise analysis, and when examined against theophylline clearance (as marker of CYP1A-related oxidant load) (70), afforded good separation between patients and controls (120)

This represents a key mechanism by which tirzepatide produces greater weight loss than diet alone despite similar caloric restriction

They work through entirely different mechanisms and are not directly comparable

There was ataxia on finger-nose-finger bilaterally