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Description

Janus Kinase 2 Most members of the JAK family are widely expressed in many cell types, except JAK3 whose expression is restricted to cells of the hematopoietic lineage (54)

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Discovery of highly potent and efficacious mc4r agonists with spiroindane N-me-1,2,4-triazole privileged structures for the treatment of obesity

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Critically, these effects were absent in 3-AR knockout mice, indicating that an intact 3-AR pathway is required for the lipolytic activity

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