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This oxidative stress damages mitochondrial DNA and surrounding cellular structures, further impairing energy output

10.1038/s41598-021-00337-z 66 GoldenbergD

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In multivariate analyses, factors predicting larger responses with tirzepatide include female sex (2.4 higher odds of achieving a 20% weight reduction), lower baseline hemoglobin A1c (1.62 higher odds), no diagnosed hypertension (1.35 higher odds), and lower ALT (1.17 higher odds) 21