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However, clinical trials using ibuprofen have not successfully modified AD disease progression or outcomes (91, 92), which may reflect a need for combination therapies to target multiple aspects of this complex disease

Modification of oxidative stress by pioglitazone in the heart of alloxan-induced diabetic rabbits

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A second Phase I study in adults with diabetic kidney disease reported a D+Q dependent clearance of senescent adipose and skin cells and reduced SASP within 11 days of treatment (106)