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While individual sensitivity varies, caffeine has a half-life of approximately 5 to 6 hours, meaning half of the caffeine from an afternoon coffee remains in your system at bedtime

Twelve studies included individuals with OCD [39,40,41, 43,44,45,46,47, 50, 51, 53, 55], four others included individuals with trichotillomania [42, 48, 52, 54], and the remaining study included individuals with excoriation disorder [49]

Given a ~1hour half-life and hourslong systemic presence, a oncedaily or everyotherday regimen during any initial phase is typically pharmacokinetically reasonable

Our body naturally produces it, mainly in the liver and kidneys

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