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Start by figuring out how long the medication stayed out of the right temperature range
Regular follow-up appointments help identify early signs of adverse effects, medication efficacy changes, or the need for dose adjustments
We should note here that the preservation of weight loss and food intake inhibition by GIPR antagonism in mice with disturbed GIPR signalling in the PNS is not unexpected, given that mice with CNS loss of Gipr (thus, mimicking the use of an antagonist) show decreased body weight and food intake when fed a HFD 15 , suggesting that the reduction in body weight by GIPR antagonism is mediated by neurons of the central rather than peripheral nervous system
Available on the World Wide Web at: www.theannals.com, DOI 10.1345/aph.1H078 Kossoff EH, Pyzik PL, Furth SL
