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METHODS A PRISMA-guided systematic review (Figure 1) was performed using PubMed and MEDLINE databases, employing search terms "glutathione" AND "topical" AND "skin" OR "dermatology," yielding 446 articles with no time restriction

Ethics approval and consent to participate This study was approved by the Ethics Committee of Childrens Hospital, Zhejiang University School of Medicine

Notably, ergothioneine emerged as the plasma metabolite most strongly linked to a decreased risk of coronary disease (p=0.01), cardiovascular mortality (p=0.002), and overall mortality (p=0.0004)