According to our data, this could be explained by higher rates of discontinuation and lower maintenance dosages used in clinical practice, compared to randomized clinical trial settings. Semaglutide (sold under the brand names Wegovy and Ozempic) and tirzepatide (sold under the brand names Zepbound and Mounjaro) are FDA-approved medications for the treatment of type 2 diabetes and chronic weight management
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes mellitus and, more recently, for weight management in specific patient populations
Combined, they may produce symptomatic hypoglycemia, particularly in patients who are also taking a sulfonylurea or insulin alongside their GLP-1
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The gradual approach allows the body to adapt to the amylin receptor activation, and clinical trial data shows that nausea rates drop substantially with proper dose escalation
