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It accomplishes this through several distinct mechanisms: Collagen and elastin stimulation: GHK-Cu upregulates the genes responsible for collagen I, collagen III, and elastin synthesis the structural proteins that give skin its firmness, bounce, and thickness
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Meanwhile, metformin effectively inhibited endometrial thickening in PCOS rats, while attenuating the overexpression of GLUT4 in the endometrium (Zhai et al., 2012)
Gillies GE, McArthur S (2010) Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
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