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Since they were first identified as therapeutic agents in 2005, glucagon-like peptide-1 receptor agonists, or GLP-1s, have evolved into a medical breakthrough in diabetes management and its comorbidities

Tirzepatide is available as two brand-name drugs: is indicated to treat type 2 diabetes in adults

doi: 10.1016/j.neuropharm.2012.03.016 177

It is effective and well-tolerated in children and adults, but special considerations must be taken for some individuals

These modifications were designed to reduce binding affinity for IGF binding proteins (IGFBPs), which normally sequester circulating IGF-1 and limit its bioavailability