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Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

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As part of the negotiation process, drug manufacturers offer rebates on many but not all brand-name medications

It is banned in professional sports by WADA but remains available in research and wellness clinics

GH-mediated downstream effects (hepatic IGF-1 production, anabolic signaling) are the proposed basis for claimed metabolic benefits, but the evidence base is limited to animal and in vitro research