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The pathogenesis of diabetes comprises various functional changes in multi-organs in response to systemic energy disarrangement, which were previously described as ominous octet by Professor Defronzo

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However, long-term studies on GLP-1RAs exposure indicate no significant changes in the risks of thyroid, bladder, or pancreatic cancers, whereas the incidence of prostate, lung, and colorectal cancers has been shown to significantly decrease [20]