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2.4 Application to AD: mapping complexity In AD research, this approach uncovers how phytochemicals modulate core pathological pathways including A aggregation, tau phosphorylation, oxidative stress, and neuroinflammation via shared molecular targets (Naseri et al., 2019)

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In parallel, clinical translation should incorporate mechanistic biomarkers and patient stratification to balance efficacy and safety, enabling the identification of subgroups most likely to benefit from ferroptosis-targeted interventions