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Recent Phase 3 TRIUMPH trial updates reported: 22.6% average weight loss in participants with obesity and cardiovascular disease 20.8% average weight loss in participants with obesity and Type 2 diabetes Approximately 1.6% HbA1c reduction in the diabetes cohort What makes retatrutide particularly interesting is its triple-agonist approach targeting GLP-1, GIP and glucagon receptors, aiming to combine appetite suppression with increased energy expenditure

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Meier JJ, Nauck MA (2005) Glucagon-like peptide 1 (GLP-1) in biology and pathology