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NICE guidance (NG69) recommends psychological interventions as first-line treatment for eating disorders

SUMMARY OF FINDINGS AND LIMITATIONS Based on the available evidence, metformin in PCOS is effective for improving insulin resistance, regulating menstrual cycles, and reducing androgen levels, with additional benefits for ovulation and some metabolic outcomesparticularly in women with elevated BMI or glucose intolerance

Two cohorts of patients were identified

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Similar changes in metabolic rates can be found in the context of exercise training and high-altitude adaptation (8, 9)