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GLP-1 drugs may be discussed as an off-label option for people who: Have moderate to severe HS Live with obesity or metabolic dysfunction Have not achieved adequate control with standard treatments Are already candidates for GLP-1 therapy for metabolic reasons Any decision to use GLP-1 medication should involve careful medical supervision and shared decision-making

Azelaic Acid: Treats pigmentation and prevents new discoloration by inhibiting tyrosinase, an enzyme needed for melanin production

Isolated ILC2s were cultured at 37 C (2 10 4 /ml) for 72 h in cRPMi supplemented with rhIL-2 (20 ng/ml

TRIUMPH-3 (NCT05882045) will investigate change in bodyweight in people with overweight/obesity and cardiovascular disease, and TRIUMPH-4 (NCT05931367) will assess change in WOMAC score and bodyweight in individuals with overweight/obesity and knee OA