Simultaneously, carotenoids accumulate in the stratum corneum, producing a gradual yellow-orange hue that becomes visible over time, particularly in low-melanin and sun protected areas such as the palms or inner arms (Figure 5)
It plays a crucial role in detoxification, cellular repair, and maintaining overall health
Sterile water lacks this preservative, meaning any contamination introduced during mixing will multiply unchecked
Therefore, alternative agents with more selective anti-inflammatory effects are being explored
In multiple clinical contexts, circulating markers such as cellfree DNA (dsDNA), myeloperoxidase (MPO)DNA complexes, and citrullinated histone H3 (CitH3) have been validated as indicators of NETosis and correlate with disease severity or activity in systemic inflammatory and thromboinflammatory disorders (e.g., cardiovascular disease, autoimmune conditions) [50, 66]