Triglyceride-lowering effects appear particularly robust in patients with elevated baseline levels
Garczorz W, Gallego-Colon E, Kosowska A, et al
Glutathione levels, including both GSH and GSSG, can be influenced by factors such as age, diet, lifestyle, and exposure to environmental toxins
LC reduces pro-oxidant ROS-generating enzymes xanthine-oxidase (XO) and nicotinamide-adenine-dinucleotidephosphate-oxidase (NADPH-oxidase), and chelates metal ions (Fe2 + , Cu +), or acts as a buffer for excessive acetyl groups, that leads to a lower mitochondrial superoxide production [32]
In OC treatment, the natural compound -sitosterol (SIT) has demonstrated the potential to strengthen the interaction between NRF2 and Keap1, promoting NRF2s ubiquitin-dependent degradation and subsequently diminishing the transcriptional activation of downstream antioxidant genes