Key Takeaways The most common side effects are digestive issues like nausea, diarrhoea, vomiting, and constipation, similar to other GLP-1 medications Some participants experienced mild increases in heart rate at higher doses, but this decreased over time Side effects are typically worse when starting treatment or increasing doses, then improve as your body adjusts Long-term side effects are unknown as trials have only lasted up to one year so far Retatrutide is still in clinical trials and not available for prescription yet By entering I agree to the Terms and Conditions
The US Food and Drug Administration has reported shortages of the GLP-1 medications Ozempic, Wegovy and Mounjaro at various dosages over the past year as drugmakers have raced to keep up with skyrocketing demand
Obesity is the entry point, but cardiovascular disease, kidney disease, MASH, sleep apnea, and metabolic syndrome may define the long-term value
Consistent with the notion that glucose uptake by BAT reflects insulin sensitivity rather than energy expenditure 36,37 , GLP-1GIPLani and GLP-1GIP did not affect expression of thermogenic genes in the BAT (Extended Data Fig
Their ability to address both weight and metabolic health issues enhances their appeal as a treatment option
