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IGF-1 is a growth factor that has a major, but not absolute, dependence on somatotropin

.,HarjumkiR,PridgeonCSIngelman-SundbergMCYP2E1 in alcoholic and Non-Alcoholic liver injury

Conclusion Dark spots over 55 become more persistent due to hormonal shifts, declining melanocyte regulation, and cumulative oxidative stress

Until Phase II and III results emerge with proper endpoints (mucosal healing rates, histologic remission, patient-reported outcomes), the evidence base will remain preclinical