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According to the results of the RCT for patients with monogenic obesity ( LEPR or POMC deficiency) and acquired hypothalamic obesity, setmelanotide can reduce body weight and inhibit appetite to a certain extent, and common adverse reactions include injection site reactions, skin hyperpigmentation, nausea, diarrhea, and abdominal pain, with occasional occurrences of sexual adverse reactions, depression, and suicidal ideation [51,52]

15 A major regulatory shift is currently underway with the introduction of the Unitary SPC, which will allow applicants to obtain a single extension covering all EU member states participating in the Unified Patent Court (UPC) system

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The most common adverse effects reported in clinical trials include nausea (38-43% at higher doses), diarrhea (33-35%), constipation (22-25%), and vomiting (20-21%)