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There apparently are no substantial interactions between the two glutathione moieties in GSSG, and the stability of this disulfide bond is comparable to that between two other cysteine residues on unfolded peptides or proteins

Drug Metab Lett [Internet]

PubMed 7(6):456 Prez OMM, Flrez-Vargas O, Cruz GR, Gonzlez FR, Rocha-Muoz LP, Rodrguez LHS (2021) Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a colombian population

Interestingly, ablation of GPX4 in T cells disrupts CD8+ T-cell homeostasis in the periphery but does not affect thymopoiesis in mice (88)

Marchetti C