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(Peptide Gurus) By mimicking the part of FOXO4 that binds p53, FOXO4-DRI competes for that interaction, frees p53, causes its nuclear exclusion and triggers apoptosis in the senescent cell, thereby selectively reducing senescent cell burden

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Intriguingly, NMR analysis estimated a stronger K D of 1907 for helix 23 (L959 = 1.0 M, K955 = 1.6 M) than for helix 14 (I936 = 27.0 M, K1032 = 25.7 M)

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