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Serious adverse events and complications of these medications may include Gastroparesis (paralysis of the stomach), NAION vision loss, Ileus, Pancreatitis, Wernickes Encephalopathy, Bowel obstruction (blocked intestine), Malnutrition requiring hospitalization, and Pulmonary aspiration while under anesthesia or during surgery

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If specific foods are repeatedly paired with discomfort, individuals may develop negative associative links through conditioned learning, thereby reducing the subjective attractiveness of those foods