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This increased transmission of pulsatile and high-pressure blood flow into the cerebral circulation is associated with cerebral microvascular damage, which contributes to chronic reductions in CBF seen with aging and disease (Suri et al., 2020)

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The theoretical concerns, chiefly copper accumulation and the thinness of formal AHK-Cu safety study, are flagged as open questions rather than dressed up as risks or waved away