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Manipulation of genes encoding enzymes for, e.g., folate biosynthetic and salvage pathway, polyglutamylation, and folate binding proteins, has been carried out with some achievements 2,10,25,34,303,310,560,752,754,776,791,792,793,794,795,796,797,798,799,800,801,802

Furthermore, both GSQs (124) and QQ-protein thiols have been shown to be unstable and transient -lasting for minutes and hours instead of days- suggesting an overestimation of the proposed in vitro toxicity (125)